How does ion mobility spectrometry work?
The larger the ions in the sample, the more frequently they collide, are slowed down more and arrive at the detector later. The ion mobility spectrometer (IMS) measures the drift velocity of the ions through the drift tube. The longer the drift time, the higher the molecular weight of the ion. Ion mobility spectrometry (IMS) is the most commonly used technique in instruments for field presumptive analysis. IMS measures the mobility of ions accelerated by a constant electric field through a drift region to a detector.Ion mobility spectrometry is particularly well-suited for use in security applications. This technique is commonly used to detect trace amounts of explosives, drugs, and other materials in various sample types. It is often used for screening at airports, borders, and other security checkpoints.IMS instruments such as microscale high-field asymmetric-waveform ion mobility spectrometry can be palm-portable for use in a range of applications including volatile organic compound (VOC) monitoring, biological sample analysis, medical diagnosis and food quality monitoring.Ion mobility spectrometers (IMS) can detect a multitude of compounds including explosives, illicit drugs, and chemical warfare agents. Responders use IMS to detect chemicals, explosives, and narcotic compounds in a variety of operating environments.
What are the advantages of ion mobility spectrometry?
The main advantages of this technique are: compact design, high sensitivity (ppb-ppt level), fast response (ms range), operation in atmospheric pressure and ability to separate isomeric compounds. Traditionally the IMS instruments consist of three major parts: ionization region, reaction region and drift tube. The core principle of IMS instrumentation is to separate ions in an inert gas (commonly termed “buffer gas”) under the influence of an electric field.
What are the applications of ion mobility mass spectrometry?
It has been used in the detection of chemical warfare agents, detection of explosives, in proteomics for the analysis of proteins, peptides, drug-like molecules and nano particles. Moreover, IM-MS can be used to monitor isomeric reaction intermediates and probe their kinetics. Ion mobility spectrometry (IMS) is widely used for the trace detection of explosives in airports and in the field as it can deliver highly sensitive real-time analysis of trace residues.IMS instruments such as microscale high-field asymmetric-waveform ion mobility spectrometry can be palm-portable for use in a range of applications including volatile organic compound (VOC) monitoring, biological sample analysis, medical diagnosis and food quality monitoring.Ion mobility spectrometry (IMS)-based trace explosives detectors are gas sampling and analysis instruments that can detect and identify a wide range of explosive compounds. These detectors are used to screen packages, vehicles, clothing, and other items for trace residues of explosives.
What is the principle of spectrometry?
Spectrophotometry is a method to measure how much a chemical substance absorbs light by measuring the intensity of light as a beam of light passes through sample solution. The basic principle is that e ach compound absorbs or transmits light over a certain range of wavelength. The principle of a spectrophotometer is based on the Beer-Lambert Law, which describes the relationship between the absorbance of light by a sample and the concentration of the absorbing substance. When light passes through a sample, some wavelengths are absorbed by the material, while others pass through.Mechanism of Spectrophotometers The basic way a spectrophotometer functions is by having a light source shine through a sample. The light that passes through the sample is then detected and measured. The amount of light absorbed, transmitted, or reflected by the sample is then calculated.Thus, in simple words the spectrophotometer is based on the Beer-Lambert Law which states that the amount of light absorbed is directly proportional to the concentration of the solute in the solution and thickness of the solution under analysis.The Beer-Lambert law states that there is a linear relationship between the concentration and the absorbance of the solution, which enables the concentration of a solution to be calculated by measuring its absorbance.A colorimeter follows the principle of Beer-Lambert Law, which states that light absorption by a solution increases with the concentration of the absorbing substance and the path length of the light. According to this law, a more concentrated solution absorbs more light.
What is the principle of ion spectroscopy?
Basic Principle Each primary product ion derived from the molecular ion, in turn, undergoes fragmentation, and so on. The ions are separated in the mass spectrometer according to their mass-to-charge ratio, and are detected in proportion to their abundance. A mass spectrum of the molecule is thus produced. Mass spectrometry has four essential functions, which are ionization, separation (filtering), detection and analysis. These functions are coordinated by the following components: the ion source, mass analyzer, detector and software.Basic Principle A mass spectrometer generates multiple ions from the sample under investigation, it then separates them according to their specific mass-to-charge ratio (m/z), and then records the relative abundance of each ion type.In the first step, the ions are separated according to their mobility through a buffer gas on a millisecond timescale using an ion mobility spectrometer. The separated ions are then introduced into a mass analyzer in a second step where their mass-to-charge ratios can be determined on a microsecond timescale.Principle of MS Mass spectrometry (MS) is an analytical technique that separates ionized particles such as atoms, molecules, and clusters by using differences in the ratios of their charges to their respective masses (mass/charge; m/z), and can be used to determine the molecular weight of the particles.What is the basic principle of mass spectrometry? A mass spectrometer generates multiple ions from the sample being investigated, then separates them by their specific mass-to-charge ratio (m/z) and then records the relative abundance of each type of ion.